Herpes Virus Infection Symptoms And Treatment In Human
pada Desember 26, 2017
Herpesvirus hominis, Epstein-Barr virus, varicella zoster virus and cytomegalovirus are important members of the herpesvirus group. The infections are widespread in the community and tend to be mild or subclinical in nature. The group commonly cause persistent or latent infections resulting in an infection carrier state.
A Herpes simplex infections
Herpes simplex infections caused by the Herpesvirus hominis are almost in man. Apart from ‘cold sores’, the commonest clinical manifestation is an acute ulcerative stomatitis. Following infection, many patients become long-term carriers. Burnett has suggested that this one of the most ancient of human infections because of the mild clinical illness, the ability to sustain the infection in small closed communities such as primitive tribes and the occurrence of an almost identical virus in other primates.
Epidemiology
Primary infection can occur at any age but is most common in the very young child. Babies in the first few mnths of life are usually immune because of transferred maternal antibody. Most primary infections are clinically inapparent and can only be detected by a rise in serum antibody. Clinically apparent infections most commonly affect the mouth, conjunctive, skin or female genital tract. These infections are short-lived and heal completely but the virus may persist for many years in the cells of the skin, particularly round the mouth and also in the trigeminal ganglion, in spite of protective levels of antibody in the blood. From time to time, because of some systemic upset there is reactivation of the latent virus with the formation of new lesions.
Both the primary and the recurrent lesions are highly infectious. Infections spreads by droplet infection, by close personal contact as in kissing and by contaminated utensils. Infection is more common and occurs at an earlier age in overcrowded or unhygienic social conditions. Two types of the virus are recognized. Type 1 is the cause of most oral conjunctivical and cutaneous infections and type 2 is the cause of most genital infection.
A closely related virus, Herpesvirus simiae (formerly herpes B virus) is commonly found in monkeys bite a highly fatal encephalitis may result.
Incubation period
This is usually 4-5 days
Clinical picture
Herpetic ulcerative stomatitis
This is the most common clinical manifestation and it occurs particularly in young children. The onset is abrupt with fever, general malaise, irritability and soreness of the mouth. A rash then apprears on the skin around the lips or occasionally more widely on the face and neck. The rash consists of painful vesicles set on an inflamed base and these may be single or in group of varying size. In a few cases there is also a generalized discrete vesicular rash on the trunk and limbs. At the same time, wide-spread painful ulceration develops in the mouth affecting the tongue, gums, palate and buccal mucosa. The mouth lesions are shallow inflamed ulcers, covered with whitish exudate which bleeds when touched. There is excess blood tinged saliva in the mouth which causes dribbling in young children. The skin vesicles and mouth ulceration persist for a week or longer together with sustained fever, the local lymph glands become enlarged. Young children frequently refuse to eat or drink.
After healing, the mucosal lesions do not recur but the skin lesions may re-appear over a period of many years, either as single or grouped vesicles usually termed ‘cold score’. The common precipitating cause of a recurrence is a febrile illness but it may follow trauma fatigue or exposure to could or sunlight.
Less common clinical presentatitions
1. Generalized infection of the newborn. This is a rare but frequently fatal form, presenting a few days after birth with vomiting convulsions, skin lesions, hepatosplenomegaly and circulatory collapse. Most of these cases are caused by type 2 virus acquired from the mother suffering from genital herpes.
2. Keratoconjunctivitis. This primary form of infection presents with painful conjunctivitis, usually unilateral. This infection may be recurrent with the formation of dendritic ulcers leading to chronic scarring and damage to vision.
3. Genital herpes. This primary infection presents with vesicular or ulcerative lesions on the vulva and cervix in the female and on penis in the male and are commonly recurrent. These condition are being increasingly recognized at VD clinics and in adult are almost certainly sexually transmitted.
4. Herpetic whitlow. This is probably a true viral wound infection and presents as an indolent inflammatory lesion arising at the site of a minor skin trauma, usually on a finger. Superficial vesiculation is often present at some stage. If the diagnosis is suspected, surgical incision is to be avoided as the lesion is self-limiting.
5. Eczema herpeticum. In patients suffering from chronic eczema, primary herpes infection of the skin causes a serious illness. In the eczematous areas, confluent vesiculation occurs, which breaks down leaving raw and weeping areas. There is high fever with a severe systemic upset and the illness may be fatal. The older name for this condition was kaposi’s varicel-liform eruption but this also embraced a similar condition caused by the vaccinia virus.
6. Herpes encephalitis. Rarely, the herpes virus may invade the nervous system either during primary infection or during a recurrence. Herpes encephalitis is a serious illness, presenting with meningeal irritation, eranial nerve lesions, convulsions and impaired consciousness leading to coma. Local areas of oedema and necrosis may lead to localizing neurological signs, sometime suggestive of a space occupying lesion. The mortality is higher than in most other form of encephalitis, varying from 20 to 60 percent in different series and the survivors often show evidence of permanent brain damage. This condition is different from the more usual post-infectious type of encephalitis which complicates viral diseases, in that the virus directly invades the brain and can be isolated from biopsy specimens and occasionally from the CSF.
Diagnosis
The diagnosis of herpes simplex infection can be readily confirmed by the isolation of the virus from superficial lesions and by rising serum antibody levels. In encephalitis a brain biopsy is necessary to establish the diagnosis rapidly.
The virus may be detected by electron by electron microscopy or immunofluorescent microscopy and grows quickly in tissue cultures, so that confirmation is possible within a very few days. Acute ulcerative stomatitis in a child is practically always due to herpesvirus. Recurrent aphthous ulceration of the mouth in adults is not due to herpesvirus.
Prognosis
Generalized infection of the newborn of the newborn and herpes encephalitis although rare are both commonly fatal. Eczema herpeticium is occasionally fatal. Keratoconjunctivitis may permanently impair vision. The other more common forms of infection are benign.
Treatment
This is largerly supportive and aims at the relief of symptoms with analgesics and mouth washes and mouth washes and the maintenance of fluid intake. Antibiotics are often prescribd but have no effect on the course of the illness.
The antiviral drugs idoxuridine (IDU), cytosine arabinoside (vidarabine) are active in vitro against herpervrus. In skin infections, local applications of indoxuridine may shorten the duration of the lesions and reduce the infectivity. In conjunctival infections local trifluorothymidine is increasingly used in preference to other antiviral drugs. In encephalitis IDU has been abandoned as being ineffective and hazardous. Adenine arabinoside (vidarabine) is the preferred drugs and is being used although there is little evidence as yet that it is beneficial. These drugs are cytotoxic and are liable to pproduce troublesome side effects particularly depression of the bone marrow and damage to the gastrointestional mucosa.
B Cytomegalovirus infection
Intrauterine infection of the fetus is fairly common and is increasingly recognized. This may result in severe generalized disease in the neonate with jaundice, hepatosplenomegaly and thrombocytopenia but more often results in brain damage alone. It is estimated that more than 400 children born in England each year suffer gross mental retardation from this cause and many more suffer a lesser degree of mental impairment.
In adults and older children, subclinical infection occurs very commonly as shown by antibody surveys. Clinical illness may occurs and the following overlapping syndromes have been described:
a - Pyrexial illness without localizing features
b - Hepatitis often with prolonged pyrexia
c - Glandular rever-like illness with negative paul-bunnell, sometimes accompanied by thrombocytopenia.
d - Acute polyneuritis of the guillain barre type
e - Post perfusion syndrome this is a severe glandular fever like illness which may follow the administrators of fresh blood in open heart surgery. This is a serious condition which may end fatally.
f - Following organ transplant surgery, there may be a pyrexial reactivation of infection with this virus, with severe pneumonitis. This is another serious condition which may be fatal.
The diagnosis is confirmed by the isolation of the virus in tissue culture from urine, blood or saliva and by the demonstration of high antibody levels in the blood.
Experimental studies in the production and use of a vaccine are now beginning but there are no other effective treatments of preventive measures